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本文从生化、生理和形态学方面对汞的神经毒性进行了综述。汞极易穿透血脑屏障,并能破坏血脑屏障的功能。经生化和电镜组织化学方法的研究,证明汞在细胞内与膜性细胞器如线粒体、内质网、高尔基氏复合体、核包膜以及溶酶体结合,仅有微量的汞分布核内。还发现在汞中毒的动物体内,其神经元中核糖核酸(RNA)和蛋白质的合成锐减,因而导致这些神经细胞最后死亡。二氯化汞(HgCl_2)长期中毒时,神经元RNA水平可重新恢复,这与动物对汞毒性的耐受性的提高是一致的。汞中毒
This article reviews the neurotoxicity of mercury from the aspects of biochemistry, physiology and morphology. Mercury easily penetrates the blood-brain barrier and can disrupt the blood-brain barrier function. Biochemical and electron microscopy histochemical methods to study mercury in the cells and membrane membranous cells such as mitochondria, endoplasmic reticulum, Golgi complex, nuclear envelope and lysosome binding, only a trace of mercury distribution in the nucleus. It has also been found that the synthesis of ribonucleic acid (RNA) and protein in neurons is sharply reduced in mercury poisoned animals, resulting in the eventual death of these nerve cells. Long-term poisoning with mercury dichloride (HgCl 2) can restore the level of neuronal RNA, which is consistent with the improvement of animal tolerance to mercury toxicity. Mercury poisoning