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目的观察与研究两种糖尿病药物联合应用对2型糖尿病者血糖影响,从而筛选一种更加合理及有效的联合用药方案。方法随机选取56例2型糖尿病者且给予二甲双胍联合罗格列酮控制血糖水平作为观察组,另外再选取55例以往仅单纯给予二甲双胍治疗的2型糖尿病者作对比研究,即对照组,对两组患者空腹血糖、餐后2 h血糖及糖化血红蛋白水平加以观察和数据的处理分析。结果观察组患者空腹血糖、餐后2 h血糖及糖化血红蛋白水平改善情况优于对照组(P<0.05)。结论以二甲双胍为基础联合罗格列酮对2型糖尿病者血糖调控具有显著作用,值得进一步推广。
Objective To observe and study the effects of two diabetes drugs on blood glucose in type 2 diabetic patients and to screen for a more reasonable and effective combination regimen. Methods Fifty-six patients with type 2 diabetes mellitus and metformin combined with rosiglitazone were given as the control group. Another 55 patients with type 2 diabetes mellitus who were treated with metformin only in the past were selected as the control group, The fasting blood glucose, postprandial blood glucose and HbA1c level in 2 groups were observed and the data were analyzed. Results The improvement of fasting blood glucose, postprandial 2-hour postprandial blood glucose and glycosylated hemoglobin in observation group was better than that in control group (P <0.05). Conclusion Metformin-based combination with rosiglitazone has a significant effect on blood glucose regulation in type 2 diabetic patients and is worth further promotion.