根管甲硝唑药尖的实验研究和临床应用

• 作 者: 李德懿 叶秀琴 张濒 潘益华 汪俊
• 机 构: 上海第二医科大学第九人民医院,上海中华制药厂
• 出 处: 牙体牙髓牙周病学杂志
• 发表日期: 2004年期
• 关键词: 根管 尖周炎 牙髓根尖周病 临床应用 抗菌药物 牙胶尖 多聚物 分离菌 产黑色素普氏菌 厌氧菌感染

目的：为适应不同粗细根管的需要，制备粗、中、细３种抗厌氧菌的甲硝唑药尖。方法：选用甲硝唑、无毒可吸收的高分子多聚物羟丙基甲基纤维素和明胶等，经化学、物理方法交网和固化而成。结果：表明它对牙髓根尖周病的重要致病菌有明显抑菌作用。３Ｈ标记的甲硝唑药尖的体外释放测定证实它能在根管内４８ｈ以上持续释放有效甲硝唑。临床上直接插入感染根管治疗急、慢性根尖周炎８０例，２ｄ～４ｄ能自行吸收，经１次～２次治疗，症状显著改善。结论：该剂型有效安全，不影响正常菌群，未见毒副反应，为合理科学应用抗菌药物开拓新途径。

Objective: To meet the needs of different thickness of the root canal preparation coarse, medium and fine anti-anaerobic metronidazole medicine tip. Methods: Metronidazole, non-toxic absorbable macromolecule polymers such as hydroxypropyl methylcellulose and gelatin, etc, were synthesized by chemical and physical methods and cured. Results: It shows that it has significant bacteriostasis on important pathogens of apical periodontal disease. 3H-labeled metronidazole tip in vitro release assay confirmed that it can continue in the root canal for more than 48h sustained release of effective metronidazole. Clinically, the direct insertion of infected root canal treatment of acute and chronic apical periodontitis in 80 cases, 2d ~ 4d can be absorbed by 1 or 2 times, the symptoms were significantly improved. Conclusion: The dosage form is effective and safe, does not affect the normal flora, no toxic and side effects, to explore new ways for rational and scientific use of antimicrobial agents.