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患者,男,43岁。于1991年8月以肝炎后肝硬化收入传染科住院治疗。即往无药物及食物过敏史,未用过马络替酯。体检一般状态尚可,面色污秽,有肝掌,皮肤巩膜轻度黄染,心肺未见异常。肝肋下可触及边,脾肋下2.0cm,质软无触痛,无腹水.实验室检查肝功转氨酶正常,ZnSO_418u,TTT19u,黄疸指数25u。HBsAg+,HBeAg+,抗-HBc+,血常规:WBC 4.0×10~9/L,RBC 3.71×10~(12)/L,Plt 18×10~9/L。给予马络替酯2片,1日3次口服,其他治疗用阿卡明,葫芦素及维生素口服。患者于用药第3天出现周身皮疹,伴有乏力及食欲减退,查体:周身皮肤可见散在点状充血性皮疹,疹子为暗紫色,略高出皮肤,粟粒大小左右,周身分布
Patient, male, 43 years old. In August 1991 to hepatitis in cirrhosis income Infectious Diseases hospitalized. That is to no drug and food allergy history, has not been used for malu for ester. Physical examination is generally acceptable, looking dirty, liver palms, skin scleral mild yellow dye, heart and lung no abnormalities. Hepatic ribs can reach the side, spleen ribs 2.0cm, soft, no tenderness, no ascites.Laboratory liver function test transaminases normal, ZnSO_418u, TTT19u, jaundice index 25u. HBsAg +, HBeAg +, anti-HBc +, blood routine: WBC 4.0 × 10-9 / L, RBC 3.71 × 10-12 / L, Plt 18 × 10-9 / L. Give maluo for two tablets, oral 3 times on the 1st, the other treatment with acamprosulfon, cucurbitacin and vitamin oral. Patients in the first 3 days of medication appeared whole body rash, accompanied by fatigue and loss of appetite, physical examination: the whole body visible scattered spots of congestive skin rash, rash is dark purple, slightly above the skin, miliary size, the whole body distribution