铝可增加鼠大脑皮层cAMP的浓度

• 作 者: 汪晓静
• 出 处: 国外医学(卫生学分册)
• 发表日期: 1987年05期
• 关键词: 大脑皮层 浓度 鸟苷酸结合蛋白 神经毒性作用 神经纤维 腺苷酸环化酶 去水吗啡 鼠脑 活性 多巴胺能激动剂

铝的性质及其神经毒性作用已成为一个引人注目的研究课题。业已证实,铝与多种神经功能紊乱有关,它可选择性地累积在紊乱的神经纤维中的神经原;在Alzheimer’s病中也可浓聚于衰老的血小板中。体外研究表明,在有NaF存在的情况下,铝能使调节腺苷酸环化酶活性的鸟苷酸结合蛋白活化,使cAMP浓度增加10倍。本文作者测定了口服或向大脑皮层

The nature of aluminum and its neurotoxicity have become an attractive research topic. Aluminum has been shown to be involved in a variety of neurological disorders, which selectively accumulate neurons in disturbed nerve fibers and in aged platelets in Alzheimer’s disease. In vitro studies have shown that aluminum activates guanylate binding protein that regulates adenylate cyclase activity in the presence of NaF, resulting in a 10-fold increase in cAMP concentration. The authors determined oral or to the cerebral cortex