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实验研究观察了当机体摄入重核裂变产物~(147)Pm后在不同时间间隔的体内蓄积过程,尤其是在生殖系统睾丸中的滞留对生殖细胞染色体畸变和精子畸形的诱发效应。研究结果表明,~(147)Pm由静脉摄入机体后在持续50d的观察过程,拟合了在睾丸内的滞留方程为: R(t)=0.1872×e~(-0.0066t)可见随着受~(147)Pm内污染时间的延长,其在睾丸内的累积吸收剂量亦随之增升。而且发现~(147)Pm可诱发精原细胞染色体结构畸变:包括裂隙、染色单体断裂、染色体断片和易位;以及染色体数目畸变的多倍体精原细胞。并随着睾丸内累积吸收剂量的增高,染色体畸变率和多倍体细胞也有所增加。同时,~(147)Pm也可诱发初级精母细胞产生染色体断片和易位,形成多价体。染色体断片率可随~(147)Pm辐照时间的延长而升高,而多价体只在内污染10d后的实验组中出现。~(147)Pm所诱发的精子畸形主要是无钩精子,且畸形率亦随吸收剂量加大而增高。
Experimental studies investigated the in vivo accumulation at various time intervals after ingestion of heavy nuclear fission product, 147Pm, in particular in the testes of the reproductive system, on germ cell chromosome aberrations and sperm deformity. The results showed that the retention equation of ~ (147) Pm in the testis was fitted as follows: R (t) = 0.1872 × e ~ (-0.0066t) after observation of ~ (147) Subject to prolonged contamination within ~ (147) Pm, the cumulative absorbed dose within the testes also increased. Moreover, ~ (147) Pm was found to induce chromosomal structural aberrations in spermatogonia including fissures, chromatid breaks, chromosomal fragments and translocations, and polyploid spermatogonia with aberrant chromosome numbers. With the increase of accumulated absorbed dose in testis, chromosome aberration rate and polyploidy also increased. At the same time, ~ (147) Pm can also induce primary spermatocytes to produce chromosomal fragments and translocations to form multivalent. Chromosome fragmentation rate increased with the (147) Pm irradiation time, while the multivalent body appeared only in the experimental group after 10 days of contamination. ~ (147) Pm induced sperm deformity is mainly no hook sperm, and the deformity rate also increased with the dose increased.