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目的 了解已口服脊髓灰质炎疫苗 (OPV)基础免疫的儿童在加强免疫前后对四川Ⅰ型脊灰野病毒的免疫水平 ,指导预防、控制乃至消灭脊灰策略的制定。方法 微量中和试验。结果 80名 4岁儿童加强免疫前对Sabin 1、Ma honey、四川株的阳性率分别为 98 8%、 93 8%、 73 8% ,GMT分别为 2 5 6 0、 49 8、 9 9,免后的阴性率分别为 98 8%、98 8%、 82 5 % ,GMT分别为 415 9、 177 9、 2 5 6。结论 4岁儿童加强免疫后的阳性率和GMT均有明显的提高 ,加强服苗对四川Ⅰ型脊灰病毒是有效的。因此 ,强化免疫对预防、控制、消灭脊灰是行之有效且十分必要的手段。
Objective To understand the level of immune response to poliovirus type Ⅰ in Sichuan before and after the immunization with oral polio vaccine (OPV) and to guide the prevention, control and even elimination of polio strategies. Method of micro neutralization test. Results The positive rates of Sabin 1, Ma honey and Sichuan strains before immunization of 80 4-year-old children were 98 8%, 93 8% and 73 8%, respectively. The GMTs were 25 600, 49 8 and 9 9, respectively The negative rates were 98 8%, 98 8% and 82 5%, respectively. The GMTs were 415 9, 177 9 and 256 respectively. Conclusion The positive rate of 4-year-old children after immunization and GMT were significantly increased, and strengthening the vaccine was effective for Sichuan type Ⅰ poliovirus. Therefore, strengthening immunity is an effective and necessary means to prevent, control and eradicate polio.