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一般认为,成熟心肌细胞属于终未分化细胞,已丧失再生能力。一旦受到缺血和乏氧的影响而导致不可逆的损伤时,心肌组织无法通过残余心肌细胞的增生或间质细胞分化修复,造成心肌细胞数量减少,并只能以纤维组织的增生来替代,从而导致心室重构和/或心功能衰竭。 继“血管新生治疗”出现以后.心肌细胞移植疗法已经成为缺血性心脏病治疗研究的热门课题。应用的靶细胞包括骨骼肌成肌细胞、胚胎心肌细胞、以及近年来发展较快的干/祖细胞等。
Generally believed that mature cardiomyocytes belong to the final undifferentiated cells, has lost its ability to regenerate. Once subjected to irreversible damage due to the effects of ischemia and hypoxia, myocardial tissue can not be repaired by residual cardiomyocyte proliferation or mesenchymal differentiation, resulting in a decrease in the number of cardiomyocytes and can only be replaced by proliferation of fibrous tissue Leading to ventricular remodeling and / or heart failure. Following the emergence of “angiogenesis” cardiomyocyte transplantation therapy has become a hot topic in the treatment of ischemic heart disease. Target cells for use include skeletal myoblasts, embryonic cardiomyocytes, and stem / progenitor cells that develop rapidly in recent years.