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目的:观察复方丹参注射液联合西药治疗早期糖尿病肾病的疗效。方法:将83例早期糖尿病肾病患者随机分为2组,对照组40例按病情常规服用降糖药和卡托普利治疗,治疗组在对照组用药基础上加用复方丹参注射液静脉滴注,2组患者分别连续治疗28天;检测2组患者治疗前后的空腹血糖、餐后2 h血糖、糖化血红蛋白和尿白蛋白排泄率。结果:总有效率治疗组为93.0%,对照组为75.0%,2组比较,差异有显著性意义(P<0.05)。治疗后,2组空腹血糖、餐后2 h血糖均较治疗前降低(P<0.05);治疗后2组餐后2 h血糖比较,差异有显著性意义(P<0.05)。治疗组糖化血红蛋白较治疗前降低(P<0.05),对照组变化不明显;2组糖化血红蛋白比较,差异有显著性意义(P<0.05)。2组24 h尿白蛋白排泄率均较治疗前降低(P<0.01),2组比较,差异有显著性意义(P<0.05)。结论:复方丹参注射液联合西药治疗早期糖尿病肾病疗效确切。
Objective: To observe the curative effect of compound Danshen injection combined with western medicine on early diabetic nephropathy. Methods: 83 patients with early diabetic nephropathy were randomly divided into two groups, 40 patients in the control group were treated with hypoglycemic agents and captopril as usual. The patients in the treatment group received compound Danshen injection intravenously , Two groups of patients were treated for 28 consecutive days; two groups of patients before and after treatment to detect fasting blood glucose, 2 h postprandial blood glucose, glycosylated hemoglobin and urinary albumin excretion rate. Results: The total effective rate was 93.0% in the treatment group and 75.0% in the control group. There was significant difference between the two groups (P <0.05). After treatment, the fasting blood glucose and 2-hour postprandial blood glucose in both groups were lower than those before treatment (P <0.05). After 2-hour postprandial blood glucose, the difference was significant (P <0.05). The glycosylated hemoglobin in the treatment group was lower than that before treatment (P <0.05), while the change in the control group was insignificant. There was significant difference between the two groups in glycosylated hemoglobin (P <0.05). The urinary albumin excretion rate in 24 hours of both groups was significantly lower than that before treatment (P <0.01). There was significant difference between the two groups (P <0.05). Conclusion: The compound Danshen injection combined with Western medicine in the treatment of early diabetic nephropathy is effective.