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31例未治ANLL中26例的骨髓细胞染色体G显带成功。14例有核型异常(53.8％)。其中5例为t(8;21)。按核型正常或异常分组,其完全缓解率无显著差异,但t(8;21)异常的病例具有共同的血液学和临床特点,较易获得缓解。对16例病人作了动态观察,发现在诱导缓解期两例病人的核型较细胞形态学能更早反映或证实化疗效果。认为动态核型研究是判断疗效的较客观可靠的指标。
The chromosomal G banding of bone marrow cells was successful in 26 cases in 31 cases of untreated ANLL. 14 cases had karyotype (53.8%). Five of these were t (8; 21). According to the normal or abnormal karyotype group, the complete remission rate was no significant difference, but t (8; 21) abnormal cases have common hematological and clinical features, easier to obtain remission. Dynamic observation of 16 patients was made and found that in the induction of remission, karyotypes of two patients were able to reflect or confirm the effect of chemotherapy earlier. Dynamic karyotyping that is more objective and reliable indicators to determine the efficacy.