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【据Hepatologly 2011年12月报道】题:胆红素和黄疸患者血清对成骨细胞的影响——肝病患者中骨质疏松症的研究进展(作者Ruiz-Gaspa S等)成骨功能低下被认为是胆汁淤积症和终末期肝病患者骨质疏松症的特征性表现。现有研究表明,该类患者发生骨质疏松可能涉及成骨功能障碍和骨破坏增加,但其发病机制仍未完全揭晓,慢性胆汁淤积症患者滞留物对骨细胞有何影响仍缺乏研究。多组数据阐述了该类患者骨质疏松症和骨代谢疾病的危险因素,但罕见涉及病理生理评估及骨骼疾病发展的内在因素。研究发现,胆红素和胆汁酸对成骨细胞的破坏作用可能导致骨质疏松症的发生;其中,未结合胆红素对培养的人类成骨细胞有决定性影响。目前,关于胆红素对成骨细胞影响的研究
[According to Hepatologly, December 2011] Title: Effect of Serum on Bone Osteoblasts in Patients with Bilirubin and Jaundice - Progress in the Study of Osteoporosis in Patients with Liver Diseases (Authors Ruiz-Gaspa S et al.) Osteogenic hypofunction is considered Is a characteristic manifestation of osteoporosis in patients with cholestasis and end-stage liver disease. The existing studies show that osteoporosis in these patients may involve osteogenesis dysfunction and bone destruction increased, but the pathogenesis has not yet been fully disclosed, and the effect of the retentate on osteoblasts in patients with chronic cholestasis is still lacking. Multiple sets of data set out the risk factors for osteoporosis and bone metabolism in this group of patients, but rare factors that are implicated in pathophysiological assessment and skeletal disease development. The study found that bilirubin and bile acids on the destruction of osteoblasts may lead to the occurrence of osteoporosis; unbound bilirubin on cultured human osteoblasts have a decisive impact. At present, the study on the impact of bilirubin on osteoblasts