论文部分内容阅读
本文对１５０例甲、乙型病毒性肝炎患者、３０例慢性血吸虫病患者和１４０例正常人作周围血Ｔ淋巴细胞亚群、细胞膜表面免疫球蛋白（ＳｍＩｇ）和Ｅ玫瑰花结形成细胞（ＥＲＦＣ）等检测。其结果表明，急、慢性病毒性肝炎患者与正常人比较，除ＥＲＦＣ明显较低外，其周围血ＯＫＴ３、ＯＫＴ４、ＯＫＴ８和ＳｍＩｇ均明显增高，尤以急性乙肝患者和血清ＨＢＶ－ＤＮＡ及ＨＢｅＡｇ阳性者更为明显，ＯＫＴ４／ＯＫＴ８比值下降，与对照组比较均有显著性差异。说明乙肝患者的Ｔ淋巴细胞亚群的变化与病毒复制有关，提示细胞免疫参与了乙肝的发病过程。
In this paper, peripheral blood T lymphocyte subsets, membrane-surface immunoglobulin (SmIg) and E-rosette forming cells (ERFCs) were studied in 150 patients with viral hepatitis A and B, 30 patients with chronic schistosomiasis and 140 healthy controls ) And other tests. The results showed that patients with acute and chronic viral hepatitis had significantly higher levels of OKT3, OKT4, OKT8 and SmIg in peripheral blood than those in normal subjects except acute ERFC, especially in patients with acute hepatitis B and serum HBV-DNA and HBeAg-positive More obvious, OKT4 / OKT8 ratio decreased, compared with the control group were significantly different. This shows that the changes of T lymphocyte subsets in hepatitis B patients are related to virus replication, suggesting that cellular immunity is involved in the pathogenesis of hepatitis B.