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[目的]探讨盐酸羟考酮注射液超前镇痛对乳腺肿瘤患者行区段切除术中的镇痛效果及血浆致痛因子的影响.[方法]本院局麻下接受乳腺区段切除术的患者 60例随机分为两组.A组患者于局麻前将盐酸羟考酮注射液 10 mg,用生理盐水稀释至 10 mL静注.B组则局麻前静注生理盐水 10 mL.记录手术切皮即刻(T1)、切皮后 10 min(T2)、手术结束时(T3)及术后 3 h(T4)患者的平均动脉压(MAP)、心率(HR)、脉搏血氧饱和度(SpO2)水平,并对患者进行 VAS疼痛评分,分别在 T1～T4时检测血浆致痛物质 5-羟色胺(5-HT)和P物质水平.记录术中局麻药使用总量及不良反应.[结果]与 B组比较,A组患者 MAP在 T1、T2时更低,HR则在T1、T2、T3时更低(P ＜0.05);A组 T1～T4时患者 VAS疼痛评分均明显更低(P ＜0.05);与T1比较,B组患者在T2～T4时血浆中 P 物质及 5-HT水平均存在不同程度升高(P ＜0.05),且高于 A组(P ＜0.05),而 A组患者术中各时间点比较无明显差异(P ＞0.05).A组患者术中局麻药总用量要明少于B组(P ＜0.05);两组术中恶心呕吐等不良反应发生率比较无明显差异(P ＞0.05).[结论]盐酸羟考酮注射液超前镇痛能够有效的缓解行乳腺肿瘤患者行区段切除术术中及术后疼痛评分,减少血浆中致痛物质水平,显著减少术中局麻药使用量.“,”[Objective]To explore the effect of oxycodone hydrochloride injection as preemptive analgesia on the analgesic effect and plasma pain-producing factors in segmental resection of breast cancer mastectomy.[Methods]A total of 60 patients who underwent segmental mastectomy in our hospital under local anesthesia were randomly divid-ed into two groups:group A and group B.Patients in group A received intravenous oxycodone hydrochloride injection 10mg dissolved in 10ml of normal saline before local anesthesia,while patients in group B were injected with 10ml of normal saline.The vital signs of MAP,HR,SpO2and VAS scores at the time of surgical incision (T1),10 min after incision (T2),at the termination of operation (T3),and 3h after the operation (T4)were recorded.Peripheral venous blood(3ml)was drawn to detect 5-HT and substance P at T1～T4.The total dose of local anesthetic and adverse re-actions during surgery were compared as well.[Results]Compared to group B,MAP in group A was lower at T1and T2,while HR was lower at T1,T2and T3(P＜0.05).Patients in group A had significantly lower VAS scores at T1～ T4than those in group B(P ＜0.05).Compared to T1,the plasma levels of substance P and 5-HT in group B were elevated to some degree at T2～ T4,which were also higher than those in group A (P ＜0.05).While there were no significant differences of substance P and 5-HT plasma levels in group A at T1～T4(P＞0.05).Compared to group B,substance P and 5-HT levels in group A were lower than those in group B at T2～T4(P ＜0.05).Mean-while,the total dose of local anesthetic in patients of group A was significantly lower than that in group B(P ＜0.05).However,there was no statistically significant difference in the incidence of adverse reactions such as nausea and vomiting between the two groups (P＞0.05).[Conclusion]Application of preemptive analgesia with oxycodone hydrochloride injection in breast cancer patients having segmental mastectomy can significantly alleviate intraoperative and postoperative pain intensity,decrease levels of plasma 5-HT and substance P,and reduce the amount of local an-esthetic used.