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通过对胆囊癌及胆囊息肉组织中P21，P53，Bcl－2癌基因蛋白的表达及PCNA半定量测定，探讨它们对胆囊痛与胆囊息肉的鉴别论断：胆囊癌的预后估计中的作用。采用免疫组织化学（ABC法），测定了40例胆囊癌，8例胆囊腺瘤到息肉组织中P21、P53、Bcl－2癌基因蛋白的表达情况及PCNA的表达强度。结果：P21．P53，Bcl－2蛋白阳性表达车在胆囊癌组织中分别为52．5％．52．5％和70％。在胆囊腺瘤性息肉中分别为0％，0％和100％。结论：检测P21，P53，Bcl－2蛋白表达情况对于胆囊痛与胆囊息肉的鉴别诊断有一定意义；P21，P53蛋白表达可能是胆囊癌预后不良的重要指标。
The expression of P21, P53 and Bcl-2 oncogene proteins in gallbladder carcinoma and gallbladder polyps and the semi-quantitative determination of PCNA were used to investigate their role in the diagnosis of gallbladder pain and gallbladder polyps. The expression of P21, P53 and Bcl-2 oncogene proteins and the expression of PCNA in gallbladder adenomas and polyps from 8 cases were determined by immunohistochemistry (ABC method). Result: P21. The positive expression of P53 and Bcl-2 protein in gallbladder carcinoma was 52.5%. 52.5% and 70%. In gallbladder adenomatous polyps, they were 0%, 0%, and 100%, respectively. Conclusion: The detection of P21, P53 and Bcl-2 protein expression has a certain significance for the differential diagnosis of gallbladder pain and gallbladder polyps. The expression of P21 and P53 protein may be an important indicator of poor prognosis of gallbladder carcinoma.