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对375名接触氯丁二烯女工和930名对照女工的生殖结局进行了回顾性队列研究。使用SAS程序包,采用x~2检验和非条件Logistic回归分析方法。结果表明,氯丁二烯作业女工的自然流产率(10.53％)、低体重儿出生率(14.78％)显著高于对照组(4.47％和8.22％, P<0.01)。控制混杂因素后的OR分别为1.59(95％可信限1.23～2.06)和1.37 (95％可信限1.09～1.72)。氯丁二烯引起的自然流产多发生在怀孕早期。本研究未发现其他生殖异常增多。
A retrospective cohort study was conducted on the reproductive outcomes of 375 women workers exposed to chloroprene and 930 women workers in control. SAS package was used, using x ~ 2 test and unconditional Logistic regression analysis. The results showed that the spontaneous abortion rate (10.53%) and low birth weight (14.78%) of female workers in chloroprene group were significantly higher than those in control group (4.47% and 8.22%, P <0.01). ORs after controlling confounders were 1.59 (95% CI, 1.23-2.06) and 1.37 (95% CI, 1.09-1.72, respectively). Neoplasia caused by chloroprene occurred in early pregnancy. No other genital abnormalities were found in this study.