Isolation, identification, and cytotoxicity of a new isobenzofuran derivative from marine Streptomyc

• 作 者: 张宏宇 谢则平 娄婷婷 姜鹏
• 机 构: Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin Uni
• 出 处: Chinese Journal of Oceanology and Limnology
• 发表日期: 2016年02期
• 关键词: derivative cytotoxicity absolute spectroscopic reasoning methoxy COSY dimethoxy

A new isobenzofuran derivative( 1) was isolated from the marine Streptomyces sp. W007 and its structure was determined through extensive spectroscopic analyses, including 1D-NMR, 2D-NMR, and ESI-MS. The absolute configuration of compound 1 was determined by a combination of experimental analyses and comparison with reported data, including biogenetic reasoning, J-coupling analysis, NOESY, and 1 H- 1 HCOSY. Compound 1 exhibited no cytotoxicity against human cells of gastric cancer BGC-823, lung cancer A549, and breast cancer MCF7.

A new isobenzofuran derivative (1) was isolated from the marine Streptomyces sp. W007 and its structure was determined through extensive spectroscopic analyzes, including 1D-NMR, 2D-NMR, and ESI-MS. The absolute configuration of compound 1 was determined by a combination of experimental analyzes and comparison with reported data, including biogenetic reasoning, J-coupling analysis, NOESY, and 1 H- 1 HCOSY. Compound 1 exhibited no cytotoxicity against human cells of gastric cancer BGC-823, lung cancer A549, and breast cancer MCF7.