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选用Ｗｉｓｔａｒ 大鼠，以三氧化二砷为受试物，采用两代一窝试验方法，观察砷的生殖发育毒性。结果显示，仔鼠出生后第１０ 、２０ 、３０ 天的体重高剂量组明显低于对照组和其它剂量组，且有显著性差异；两代大鼠的受孕率和幼仔哺育成活率高剂量组明显低于对照组和低剂量组，正常分娩率和幼仔出生存活率各组间无显著性差异；仔鼠体砷含量随染砷剂量的增加而增加，各组间比较均有显著性差异；高剂量染砷组脾和胸腺脏器系数明显低于对照组，Ｈｂ 、ＴＬＣ 显著降低，其它剂量组免疫学指标改变不明显。结果表明，砷可影响动物的生育能力，并可通过胎盘屏障影响子代的生长发育和生理功能
Wistar rats were selected to arsenic trioxide as a test substance, using two generations of a litter test method to observe the reproductive and developmental toxicity of arsenic. The results showed that the offspring rats born at 10, 20 and 30 days after birth were significantly lower than the control group and other dose groups, and there was a significant difference between the two groups. The pregnancy rate and the survival rate Group was significantly lower than the control group and low dose group, the normal delivery rate and the survival rate of pups were no significant difference between the groups; arsenic content in offspring rats with arsenic dose increased, the comparison between the groups were significant The coefficient of spleen and thymus in high-dose arsenic-treated group was significantly lower than that in control group, Hb and TLC were significantly decreased, but the other immunological indexes were not changed obviously. The results show that arsenic can affect the fertility of animals and can affect the growth and physiological function of offspring through the placental barrier