河南人群中基质金属蛋白酶3Lys45G1u基因多态性与食管鳞癌遗传易感性的关联分析(英文)

• 出 处: Chinese-German Journal of Clinical Oncology
• 发表日期: 2009年09期
• 关键词: Henan chuan esophageal susceptibility 基质金属蛋白酶 Hubei genotype 鳞癌 squamous 遗传易感性

Objective: The aim of the study was to investigate the association of esophageal squamous cell carcinoma (ESCC) genetic susceptibility with the single nucleotide polymorphism (SNP) rs679620 (-Lys45Glu-) in exon 2 of the mmp3 gene, and the population in high incidence region of Henan (China) was selected for exploring the mechanism by case-control study. Methods: The mmp3 SNP was genotyped by PCR-RFLP analysis in total 605 cases of Henan population, in which there were 227 ESCC cases and 197 controls of An-yang in Henan plus 181 controls of emigrants in Hubei from Xi-chuan of Henan, China. Results: The statistic data showed that G/G and G/A genotype frequencies of SNP rs679620 were significantly different between the controls of emigrants of Xi-chuan in Hubei and controls of An-yang in Henan (P < 0.01) also the ESCC cases of An-yang in Henan (P < 0.01), respectively. Conclusion: This study suggests that the SNP rs679620 (-Lys45Glu-) in exon 2 of the mmp3 gene might be associated with ESCC genetic susceptibility.

Objective: The aim of the study was to investigate the association of esophageal squamous cell carcinoma (ESCC) genetic susceptibility with the single nucleotide polymorphism (SNP) rs679620 (-Lys45Glu-) in exon 2 of the mmp3 gene, and the population in high incidence region of Henan (China) was selected for exploring the mechanism by case-control study. Methods: The mmp3 SNP was genotyped by PCR-RFLP analysis in total 605 cases of Henan population, where there were 227 ESCC cases and 197 controls of An -yang in Henan plus 181 controls of emigrants in Hubei from Xi-chuan of Henan, China. Results: The statistic data showed that G / G and G / A genotype frequencies of SNP rs679620 were significantly different between the controls of emigrants of Xi- chuan in Hubei and controls of An-yang in Henan (P <0.01) also the ESCC cases of An-yang in Henan (P <0.01), respectively. Conclusion: This study suggests that the SNP rs679620 (-Lys45Glu-) in exon 2 of the mmp3 gene might be associated with ES CC genetic susceptibility.