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目的探讨高血压患者血清TNF-α及IL-6水平的变化与高血压的关系。方法采用放射酶联免疫法检测在本院就诊的163例不同程度的高血压患者治疗前后血清TNF-α及IL-6水平的变化,同期选择50例健康志愿者检测其TNF-α及IL-6水平。结果高血压患者血清TNF-α、IL-6水平均高于健康对照组,差异具有统计学意义(P<0.05),随着血压升高,血清TNF-α及IL-6水平均明显升高(P<0.05),治疗后高血压患者血清TNF-α、IL-6水平均有不同程度降低(P<0.05)。结论高血压患者TNF-α、IL-6水平升高,与血压水平呈相关,对评估高血压病严重程度和其治疗效果具有重要的临床意义。
Objective To investigate the relationship between the changes of serum TNF-α and IL-6 in patients with hypertension and hypertension. Methods Serum levels of TNF-α and IL-6 were measured by radioimmunoassay in 163 patients with different degrees of hypertension before and after treatment. 50 healthy volunteers were enrolled in this study. The levels of TNF-α and IL- 6 levels. Results The levels of serum TNF-α and IL-6 in patients with hypertension were significantly higher than those in healthy controls (P <0.05). The levels of TNF-α and IL-6 in serum were significantly increased with the increase of blood pressure (P <0.05). After treatment, the levels of serum TNF-α and IL-6 in hypertensive patients decreased to some extent (P <0.05). Conclusion The levels of TNF-α and IL-6 in patients with hypertension are correlated with the level of blood pressure, which is of important clinical significance in assessing the severity of hypertension and its therapeutic effect.