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钙拮抗剂的使用已十分普及,但其与细胞代谢中的Ca~(2+)在药理及临床应用方面的差别还较大,这就有必要对这些物质的病理学进行更广泛的研究。Ca~(2+)可以从细胞内释放出来,也可以由“钙通道”进入细胞。钙通道主要包括受体控制通道(ROC)和电压控制通道(VOC),ROC的激活方式是激活剂;VOC的激活方式是细胞膜的去极化。其中VOC又分三种形式,即持续作用型(L型),短期作用型(T型)和神经元型(N型)。在大多数细胞中,主要存在L及T型;在神经元组织中仅存在N型。
The use of calcium antagonists has become widespread, but their differences from the pharmacological and clinical applications of Ca2 + in cellular metabolism are considerable and there is a need for more extensive studies of the pathologies of these substances. Ca ~ (2+) can be released from the cell, also can be “calcium channel” into the cell. Calcium channels mainly include receptor control channel (ROC) and voltage control channel (VOC). The activation of ROC is an activator. The activation of VOC is the depolarization of cell membrane. VOC which is divided into three forms, namely, sustained-action (L type), short-acting type (T type) and neuron type (N type). In most cells, there are mainly L and T types; there are only N types in neuronal tissue.