论文部分内容阅读
目的评价双环醇片对肿瘤化疗药物所致肝损害的治疗和预防作用。方法口服双环醇片75mg·d-1治疗28例化疗药物性肝损害的患者。肝功能恢复正常后再次按照原方案化疗,同时口服双环醇片75mg·d-1形成自身对照,比较两种治疗方式患者肝功能的变化。结果口服双环醇片75mg·d-1中位治疗11d后,肝功能显著恢复。单纯化疗1个周期后转氨酶和胆红素升高程度显著高于预防性并用双环醇片化疗2个周期后(P均<0.001)。结论双环醇片75mg·d-1可有效治疗和预防化疗药物对肝脏的损害。
Objective To evaluate the therapeutic and preventive effects of bicyclol tablets on liver damage caused by chemotherapy drugs. Methods A total of 28 patients with chemotherapy-induced liver injury were treated with 75 mg · d-1 bicyclol. Liver function returned to normal once again according to the original chemotherapy, while oral bicyclol tablets 75mg · d-1 to form their own control, comparing the two treatment methods in patients with liver function changes. Results After treatment with 75 mg · d-1 oral bicyclol for 11 days, the liver function recovered significantly. The increase of aminotransferase and bilirubin after 1 cycle of chemotherapy alone was significantly higher than that of prophylactic plus cyclophosphamide after 2 cycles of chemotherapy (P <0.001). Conclusion Bicyclic alcohol tablets 75mg · d-1 can effectively treat and prevent the damage to the liver by chemotherapy drugs.