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目的 从细胞浆表达水平对谷胱甘肽Ｓ转移酶π（ＧＳＴ－π）在肾细胞癌及正常肾组织中的表达机制进行探讨，以期为选择化疗方案提供参考，获得更有效的化疗效果。 方法 应用免疫组化对肾癌及正常肾组织中ＧＳＴ－π进行检测，并结合临床分级、分型、分期探讨其临床及生理意义。 结果 ９６．３％ 的正常组织及４１．４％ 癌组织有ＧＳＴ－π表达，前者表达强于后者，表达强度与分级、分型、分期无关。 结论 各型肾癌均来源于肾近曲小管上皮，它继承了正常肾组织ＧＳＴ－π高表达的特性，发挥解毒作用而产生天然性多药耐药（ＭＤＲ）。选择ＧＳＴ－π低表达的患者并且针对ＭＤＲ机制采用相应的化疗药物进行化疗将有助于提高化疗有效率。
Objective To investigate the expression of glutathione S-transferase π (GST-π) in renal cell carcinoma and normal renal tissue from the cytoplasm expression level in order to provide a reference for the selection of chemotherapy regimens and to obtain more effective chemotherapeutic effects. Methods Immunohistochemistry was used to detect GST-π in renal cell carcinoma and normal renal tissues. The clinical and physiological significance of GST-π was analyzed with clinical classification, classification and staging. Results The expression of GST-π in 96.3% of normal tissues and 41.4% of cancerous tissues was stronger than that in the latter. The expression intensity was not related to the grade, classification and staging. Conclusion All types of renal cancer originate from renal proximal tubule epithelium. They inherit the high expression of GST-π in normal kidney tissue, exert the detoxification effect and produce natural multidrug resistance (MDR). Selecting patients with low expression of GST-π and chemotherapy with the appropriate chemotherapeutic agents for MDR mechanisms will help improve the efficiency of chemotherapy.