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我院自1991年以来用制霉菌素、强的松及维生素B_2联合治疗婴儿鹅口疮42例,经临床与单用制霉菌素37例对照观察疗效显著,现报告如下。 1.临床资料 门诊鹅口疮患儿79例,年龄0～1岁,按就诊顺序随机分成两组。治疗组42例,男28例,女14例,其中新生儿30例,对照组37例,男26例,女11例,新生儿18例,两组性别及年龄差异无显著性意义(P>0.05)。诊断标准:口腔粘膜有典型的乳白色绒状膜覆盖,呈点状或片状,不易拭去,其中9例做口腔粘膜细菌培养,证实为白色念珠菌。 治疗方法:治疗组给予制霉菌素片50万u、强的松片2.5mg、维生素B_2片5mg,对照组单用制霉菌素片100万u,均研成细粉末,加入熟芝麻油10ml配成混悬液,仅用于涂抹口腔粘膜患处,每日1～2次。若药物剂量加倍,芝麻油剂量相应加倍。疗效标准判断:从治疗开始后即观察记录口腔粘膜乳白色绒状膜消失情况,并逐日加以记录。口腔粘膜病变消失为治愈。
In our hospital since 1991, nystatin, prednisone and vitamin B_2 combined treatment of infant thrush 42 cases, clinical and single use of nystatin 37 cases observed significant effect of control, are as follows. 1. Clinical data Outpatient thrush children 79 cases, aged 0-1 years old, according to the order of treatment were randomly divided into two groups. The treatment group 42 cases, 28 males and 14 females, including 30 newborns, control group 37 cases, 26 males and 11 females, 18 newborns, the two groups of gender and age was no significant difference (P> 0.05). Diagnostic criteria: Oral mucosa with typical milky velvet covered, dot or sheet, not easy to wipe off, of which 9 cases of oral mucosal bacterial culture, confirmed as Candida albicans. Treatment: The treatment group given nystatin tablets 500000 u, prednisone tablets 2.5mg, vitamin B 2 tablets 5mg, the control group alone with nystatin tablets 1000000 u, were grind into a fine powder, add cooked sesame oil 10ml dubbed Suspension, only for smear oral mucosa affected area, 1 or 2 times a day. If the drug dose doubled, the corresponding increase in sesame oil dose. Efficacy criteria to determine: From the beginning of treatment that records the disappearance of oral mucosal velvet film, and daily record. Oral mucosal lesions disappear as cured.