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目的 :探讨抗肿瘤药物对恶性肿瘤患者免疫功能的影响。方法 :采用流式细胞术对 82例恶性肿瘤患者化疗前后免疫活性细胞进行监测。结果 :化疗前CD+3 、CD+4 、CD+8及NK细胞明显降低 ,B细胞明显增高 ;化疗后CD+3 、CD+4 显著增高 ,几乎达到正常对照组水平 ,而NK细胞进一步降低 ,B细胞则进一步增高。CD+4 /CD+8比值 ,化疗前与正常对照组无明显差异 ,化疗后则明显增高 ,并超出正常范围。结论 :恶性肿瘤患者细胞免疫功能处于抑制状态 ,体液免疫功能增强 ;抗肿瘤药物对机体免疫功能仅造成部分性损害 ,临床治疗应以调节细胞免疫功能为主
Objective: To explore the effect of antitumor drugs on immune function in patients with malignant tumors. Methods : Flow cytometry was used to monitor the immune active cells before and after chemotherapy in 82 patients with malignant tumors. Results: Before chemotherapy, CD+3, CD+4, CD+8 and NK cells were significantly decreased, B cells were significantly increased; after chemotherapy, CD+3 and CD+4 were significantly increased, almost reaching the level of normal control group, while NK cells were further decreased. B cells are further increased. The ratio of CD+4/CD+8 was not significantly different from that of the normal control group before chemotherapy, but it was significantly higher after chemotherapy and exceeded the normal range. Conclusion: The cellular immune function of patients with malignant tumors is inhibited and the humoral immune function is enhanced. Antitumor drugs only cause partial damage to the body’s immune function. Clinical therapy should be based on the regulation of cellular immune function.