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基于硼砂溶液中Ru(bpy)32+的弱电化学发光信号可被苯磺酸顺阿曲库铵增敏,建立了测定苯磺酸顺阿曲库铵的电化学发光(ECL)新方法。在最佳条件下,苯磺酸顺阿曲库铵浓度在2.0×10-6～3.2×10-5mol/L范围内与其相对发光强度呈线性关系(r2=0.9999),检出限为4.0×10-8mol/L(S/N=3)。重复测定高、低浓度(2.4×10-5mol/L,3.2×10-6mol/L)的苯磺酸顺阿曲库铵溶液9次,其RSD均为3.2%,方法具有较好的重现性。方法已用于注射用苯磺酸顺阿曲库铵的测定。
A new electrochemiluminescence (ECL) method for the determination of cisatracurbehenyl benzenesulfonate was established based on the weak chemiluminescence signal of Ru (bpy) 32+ in borax solution, which can be sensitized by cisatracurium benzenesulfonate. Under optimum conditions, cisatracurium benzenesulfonate showed a linear relationship with its relative luminescence intensity (r2 = 0.9999) in the range of 2.0 × 10-6 ~ 3.2 × 10-5mol / L with a detection limit of 4.0 × 10-8 mol / L (S / N = 3). Repeated determination of high and low concentration (2.4 × 10-5mol / L, 3.2 × 10-6mol / L) cisatracurium besylate solution 9 times, the RSD were 3.2%, the method has a good reproducibility Sex. The method has been applied to the determination of cisatracurium benzenesulfonate for injection.