论文部分内容阅读
目的探讨肾上腺皮质激素对于以蛋白尿为主要临床表现IgA肾病治疗临床效果及安全性。方法选取岳阳市一人民医院经肾活检确诊IgA肾病,病理分级Hass分级(Ⅰ~Ⅲ级),24 h尿蛋白定量在1~3.5 g;分为试验组及对照组,试验组给予激素,同时给予降压、抗凝等对症治疗,对照组给予降压、抗凝等对症治疗;随访时间为6个月,完成治疗和随访患者共48例,其中试验组25例,对照组23例,分别观察两组治疗前后24 h蛋白尿变化、内生肌酐清除率等指标。结果两组服药治疗6个月后,试验组尿蛋白定量均好转,两组内生肌酐清除率无明显变化。结论激素治疗以蛋白尿为主IgA肾病临床疗效肯定。
Objective To investigate the clinical effect and safety of adrenal cortex hormones in the treatment of IgA nephropathy with proteinuria as its main clinical manifestations. Methods IgA nephropathy was diagnosed by renal biopsy in one People’s Hospital of Yueyang City. The pathological grade Hass grading (Ⅰ ~ Ⅲ grade) and 24 h urinary protein were quantified between 1 and 3.5 g. The experimental group and the control group were divided into experimental group and control group. Given antihypertensive, anticoagulant and other symptomatic treatment, the control group given antihypertensive, anticoagulant and other symptomatic treatment; follow-up time was 6 months, the completion of treatment and follow-up of 48 patients in total, of which 25 cases in the experimental group, 23 cases in the control group, respectively The changes of proteinuria and endogenous creatinine clearance were observed 24 h before and after treatment. Results After six months of treatment, urinary protein in the experimental group was improved, and the endogenous creatinine clearance rate did not change significantly in both groups. Conclusion The clinical effect of hormone therapy on proteinuria-based IgA nephropathy is positive.