雌激素受体双核苷酸重复多态性与微型或轻型子宫内膜异位症的关系

• 作 者: Sung H.K. Young M.C. Jong K.J. 李跃萍
• 机 构: Dr.Department of Obstetrics and Gynecology Institute of Reproductive Medicine and Population Seoul
• 出 处: 世界核心医学期刊文摘(妇产科学分册)
• 发表日期: 2006年02期
• 关键词: 子宫内膜异位症 雌激素受体 核苷酸 多态性 雌激素 腺嘌呤 等位基因 等位基因分布 频率 异位

The present study was designed to explore the association between estrogen receptor-αgene polymorphism and the risk of endometriosis by investigating the frequecy of PvuII, XbaI, and thymine-adenine (TA) repeat polymorphisms in patients with and without endometriosis in a Korean population. Although there was no significant difference in the allele distribution and frequency of either PvuII or XbaI polymorphisms between endometriosis patients and control subjects, patients with stage I/II endometriosis showed a higher incidence of alleles with fewer (TA)n repeats (12-15 repeats) compared with controls.

The present study was designed to explore the association between estrogen receptor-α gene polymorphism and the risk of endometriosis by investigating the frequecy of PvuII, XbaI, and thymine-adenine (TA) repeat polymorphisms in patients with and without endometriosis in a Korean population. there was no significant difference in the allele distribution and frequency of either PvuII or XbaI polymorphisms between endometriosis patients and control subjects, patients with stage I / II endometriosis showed a higher incidence of alleles with fewer (TA) n repeats (12-15 repeats) compared with controls.