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目的:考察非聚氯乙烯(PVC)多层共挤膜输液袋、聚丙烯(PP)输液瓶和玻璃瓶3种材质输液容器对盐酸博来霉素的吸附性。方法:取相同量的盐酸博来霉素加入3种包装材质的2种输液(5%葡萄糖注射液和5%葡萄糖氯化钠注射液)中,混合均匀后分别于0、6、24、48h时取样,采用高效液相色谱法测定药物浓度,与0h时浓度相比计算相对百分含量。结果:48h时,溶媒分别为5%葡萄糖注射液和5%葡萄糖氯化钠注射液时,在PP输液瓶中,盐酸博来霉素A2、B2相对百分含量分别为90.81%、89.56%和55.65%、82.4%;而在另2种材质包装的2种溶媒中,盐酸博来霉素A2、B2相对百分含量均大于95%。结论:3种材质中,以PP输液瓶对盐酸博来霉素吸附性最强,尤其是在以5%葡萄糖氯化钠注射液为溶媒时;临床使用该药时应避免选用该材质输液瓶。
OBJECTIVE: To investigate the adsorption of bleomycin hydrochloride by infusion containers of non-polyvinyl chloride (PVC) multi-layer co-extruded film, polypropylene infusion bottles and glass bottles. Methods: The same amount of bleomycin hydrochloride was added into two kinds of infusion solutions (5% dextrose injection and 5% dextrose sodium chloride injection) of 3 kinds of packaging materials, and the blends were uniformly mixed at 0, 6, 24 and 48 h When sampling, using high performance liquid chromatography determination of drug concentration, compared with the 0h concentration relative percentage calculated. Results: The relative percentages of bleomycin A2 and B2 in PP infusion bottles were 90.81% and 89.56% at 48h and 5% dextrose and 5% dextrose and sodium chloride injection, respectively 55.65% and 82.4%, respectively. The relative percentages of bleomycin hydrochloride A2 and B2 were all higher than 95% in the other two kinds of media. Conclusion: Among the three kinds of materials, PP infusion bottle has the strongest adsorption to bleomycin hydrochloride, especially when using 5% glucose and sodium chloride injection as solvent. When using this medicine in clinic, it should avoid choosing infusion bottle .