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目的:探讨单唾液酸四己糖神经节苷酯治疗新生儿缺氧缺血性脑病的效果观察。方法:将我院收治的缺氧缺血性脑病患儿50例随机分为2组观察组和对照组各25例。观察组在常规治疗的基础上,给予单唾液酸四己糖神经节苷酯治疗,对照组在常规治疗的基础上给予脑活素治疗,比较2组患儿的临床疗效。结果:观察组的总有效率为100%,对照组的总有效率为56%,观察组的总有效率明显优于对照组,2组比较,差异具有统计学意义(P<0.05)。结论:单唾液酸四己糖神经节苷酯治疗新生儿缺氧缺血性脑病的临床效果显著优于脑活素治疗效果,有利于疾病在急性期的快速恢复,缩短病程,提高患儿的生存质量,降低致死率和死亡率,值得临床推广应用。
Objective: To investigate the effect of monosialotetrahexosyl ganglioside in neonatal hypoxic-ischemic encephalopathy. Methods: Fifty children with hypoxic-ischemic encephalopathy admitted to our hospital were randomly divided into two groups of observation group and control group of 25 cases. The observation group was given monosialotetrahexosyl ganglioside on the basis of routine treatment. The control group was treated with cerebrolysin on the basis of routine treatment, and the clinical efficacy was compared between the two groups. Results: The total effective rate was 100% in the observation group and 56% in the control group. The total effective rate in the observation group was significantly better than that in the control group. The difference was statistically significant (P <0.05). Conclusion: The clinical effect of monosialotetrahexosyl ganglioside in treating neonatal hypoxic-ischemic encephalopathy is significantly better than that of cerebrolysin, which is beneficial to the rapid recovery of the disease in the acute phase, shortening the course of disease and increasing the children’s Quality of life, reduce mortality and mortality, worthy of clinical promotion and application.