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目的探讨厄贝沙坦氢氯噻嗪早期联合美托洛尔治疗老年心力衰竭患者的临床效果。方法选取2014年7月至2015年4月沈阳市第九人民医院收治的103例老年心力衰竭患者作为研究对象,按照随机数字表法将其分为研究组(52例)和对照组(51例)。在常规治疗基础上,对照组患者则采用美托洛尔治疗,研究组患者采用厄贝沙坦氢氯噻嗪联合美托洛尔进行治疗,比较两组患者的临床治疗效果、治疗前后心功能改善情况、不良反应发生情况及复发情况。结果研究组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后,研究组患者在心率(HR)、收缩压(SBP)及左室舒张末期内径(LVEDD)均明显低于对照组,左心室射血分数(LVEF)明显高于对照组,差异均有统计学意义(均P<0.05);研究组患者的复发率明显低于对照组,差异有统计学意义(χ~2=6.90,P<0.01)。结论采用厄贝沙坦氢氯噻嗪早期联合美托洛尔治疗老年心力衰竭患者可有效改善其心功能,提高临床治疗效果,降低复发率,且安全性较高。
Objective To investigate the clinical efficacy of irbesartan and hydrochlorothiazide combined with metoprolol in the treatment of elderly patients with heart failure. Methods A total of 103 elderly patients with heart failure admitted to the Ninth People’s Hospital of Shenyang from July 2014 to April 2015 were selected and divided into study group (52 cases) and control group (51 cases ). On the basis of conventional treatment, patients in the control group were treated with metoprolol. Patients in the study group were treated with irbesartan and hydrochlorothiazide combined with metoprolol. The clinical effects, the improvement of heart function before and after treatment were compared between the two groups. Adverse reactions and recurrence of the situation. Results The total effective rate of treatment in study group was significantly higher than that in control group (P <0.05). After treatment, the study group had significant differences in heart rate (HR), systolic blood pressure (SBP) and left ventricular end-diastolic diameter LVEDD) were significantly lower than the control group, left ventricular ejection fraction (LVEF) was significantly higher than the control group, the difference was statistically significant (all P <0.05); the recurrence rate of study group was significantly lower than the control group, the difference was Statistical significance (χ ~ 2 = 6.90, P <0.01). Conclusion The combination of irbesartan and hydrochlorothiazide early metoprolol in the treatment of elderly patients with heart failure can effectively improve the cardiac function, improve the clinical effect, reduce the recurrence rate and have higher safety.