Oleanolic acid and ursolic acid inhibit proliferation in transformed rat hepatic oval cells

• 作 者: Yu-Ying Han Xiao-Wei Xue Zheng
• 机 构: DepartmentofMedicalGenetics,DepartmentofPathologyandPhysiology,DepartmentofSurgery
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2014年5期
• 关键词: OXIDATIVE stress HEPATOCARCINOGENESIS MALIGNANT TR Oxidative stress Hepatocarci
• 基金项目: The Natural Science Foundation of Beijing Municipality,China,No.7112010,the National Natural Science Foundation of China,No.81272757,the Education Commission Research Program of Beijing Municipality,C

AIM: To investigate H2O2-induced promotion proliferation and malignant transformation in WB-F344 cells and anti-tumor effects of ursolic acid(UA) and oleanolic acid(OA). METHODS: WB-F344 cells were continuously exposed to 7 x 10-7mol/L H2 O2 for 21 d. Obs