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选择28例单用预混胰岛素治疗血糖控制不佳的超重2型糖尿病患者,即空腹血糖(FBG)>8.0mmol/L、餐后2小时血糖(2hPBG)>11.1mmol/L,糖化血红蛋白(HbA1c)≧7.0%,BMI≧24kg/m2者。观察组在原预混胰岛素治疗基础上加用亚莫利,观察血糖控制达标时的胰岛素剂量。治疗12周后,比较联合亚莫利前后FBG、2hPBG、糖化血红蛋白(HbA1c)、体重指数(BMI)、每天胰岛素剂量(U)等指标。结果亚莫利联合预混胰岛素治疗达标12周后,可显著降低血糖、HbA1c,而且减少预混胰岛素剂量。比较两组患者体重指数,差异没有统计学意义,但是,观察组患者调整胰岛素治疗后的体重增加较治疗组略明显。结论单用预混胰岛素治疗的超重2型糖尿病患者血糖控制不佳时,加用亚莫利后既能显著改善血糖控制,又能减少胰岛素的剂量;另外患者的体重也无明显增加。
28 patients with over-type type 2 diabetes with poor glycemic control were selected for the treatment of overweight type 2 diabetes with fasting blood glucose (FBG> 8.0mmol / L, 2hPBG> 11.1mmol / L, HbA1c ) ≧ 7.0%, BMI ≧ 24kg / m2 who. In the observation group, Yamoglu was added on the basis of the premixed insulin therapy, and the insulin dose was observed when the glycemic control reached the standard. After 12 weeks of treatment, the indexes of FBG, 2h PBG, HbA1c, BMI and insulin dosage per day (U) were compared before and after combined with Yamoxil. Results Yamouli combined premixed insulin treatment for 12 weeks after the standard, can significantly lower blood glucose, HbA1c, and reduce the premixed insulin dose. There was no significant difference in body mass index between the two groups. However, the body weight gain after insulin treatment was slightly higher in the observation group than in the treatment group. Conclusions When blood glucose is not controlled well in patients with overweight type 2 diabetes mellitus treated with premixed insulin alone, the addition of yamoxil can not only significantly improve blood sugar control but also reduce the dosage of insulin. In addition, the body weight of patients with no symptoms is significantly increased.