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目的：探讨新一代降血压药洛沙坦对血管的保护作用。方法：由高血压组（ＳＨＲ）和正常血压对照组（ＷＫＹ鼠）组成，其中ＳＨＲ组再分为治疗组（予洛沙坦２０ｍｇ／ｋｇ·ｄ）和非治疗组，于八月龄测量鼠尾动脉压、外周血淋巴细胞内游离钙浓度及电子显微镜下血管指标。结果：与正常血压对照组比较，高血压鼠外周血淋巴细胞内游离钙浓度增高（ Ｐ＜ ０．００１），病理上表现有血管内皮细胞肥大（Ｐ＜０．０５），血管腔表面粗糙变形。而经洛沙坦治疗后与非治疗组比较，治疗组细胞内钙超负荷得到逆转（Ｐ＜０．０１），血压显著下降（Ｐ＜０．００１），血管内皮损伤得到修复（Ｐ＜０．００１），接近正常对照组水平。结论：洛沙坦能逆转高血压鼠的钙超负荷现象，在降低动脉压的同时，有效地保护血管内膜。
Objective: To explore the protective effect of losartan on the blood vessels of a new generation of antihypertensive drugs. Methods: The SHR group and normal blood pressure control group (WKY mice) were divided into two groups: SHR group (losartan 20 mg / kg · d) and non-treatment group Tail arterial pressure, intracellular free calcium concentration in peripheral blood lymphocytes and vascular indicators under electron microscopy. Results: Compared with the normal blood pressure control group, the intracellular free calcium concentration in the peripheral blood lymphocytes of hypertensive mice increased (P <0.001), and the pathological changes showed hypertrophy of vascular endothelial cells (P <0.05) . Compared with non-treatment group, losartan treatment reversed the intracellular calcium overload (P <0.01), blood pressure decreased significantly (P <0.001), vascular endothelial injury was repaired (P0.01) .001), close to the normal control group level. Conclusion: Losartan can reverse the calcium overload in hypertensive rats, while reducing arterial pressure and effectively protecting the intima.