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到目前为止吗啡仍是临床上最有效的镇痛药物之一。然而这类药物连续应用具有明显的耐受和成瘾作用,一旦停药即发生戒断症状,表现为兴奋、流涕、多汗、震颤、呕吐、腹泻、甚至虚脱,称为躯体性依赖。因此,寻找镇痛较果更好,而且不引起成瘾的药物,具有非常重要的意义:研究阿片类药物镇痛和产生成瘾的机理也是多年来的重要课题,其中应用不可逆配体作为研究阿片受体结构与功能的工具药是近年来国内外学者重视的手段,α-
Morphine is still one of the most clinically effective analgesics so far. However, continuous application of such drugs has obvious effects of tolerance and addiction. Once the drug is withdrawn, withdrawal symptoms such as excitement, runny nose, hyperhidrosis, tremor, vomiting, diarrhea and even prostration are called somatic dependence. Therefore, it is of great significance to find a drug that has a better analgesic effect and does not cause addiction. Research on the mechanism of opioid analgesia and addiction has also been an important topic for many years. The application of irreversible ligands as research Opioid receptor structure and function of the drug is a tool that scholars at home and abroad in recent years attention, α-