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目的介绍近年来抑癌基因p53和癌基因c-erbB-2与胃癌关系的研究进展。方法收集近年来国内、外关于胃癌中p53和c-erbB-2的相关文献并进行综述。结果 p53基因突变和c-erbB-2的过表达是胃癌发生中的常见事件。p53突变与胃癌的发生部位及其侵袭性生物学行为有关;c-erbB-2的过表达可作为判断胃癌预后的独立参数。针对p53及c-erbB-2的基因靶向治疗药物也在不断研究中。结论深入研究p53与c-erbB-2基因在胃癌发生、发展中的作用,将有助于清楚地认识胃癌的生物学行为,并为胃癌的基因治疗提供理论依据。
Objective To introduce the research progress of the relationship between tumor suppressor gene p53 and oncogene c-erbB-2 and gastric cancer in recent years. Methods The literature about p53 and c-erbB-2 in gastric cancer at home and abroad in recent years was collected and reviewed. Results p53 gene mutation and c-erbB-2 overexpression are common events in gastric carcinogenesis. The mutation of p53 is related to the location of gastric cancer and its biological behavior. The overexpression of c-erbB-2 can be used as an independent parameter to judge the prognosis of gastric cancer. Gene-targeted therapies targeting p53 and c-erbB-2 are also under investigation. Conclusion In-depth study of p53 and c-erbB-2 gene in the occurrence and development of gastric cancer will help to clearly understand the biological behavior of gastric cancer and provide a theoretical basis for gene therapy of gastric cancer.