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肿瘤转变涉及肿瘤抑制基因、原癌基因和转录调节基因突变多步过程 ,从而导致细胞异常表达蛋白和增殖失调控。而在这一系列过程中肿瘤细胞又通过下列途径逃脱机体的免疫监视和清除 :(1 )肿瘤抗原缺陷 :肿瘤于克隆进化或初始阶段即下调表达或不表达其特异性抗原及MHC分子 ;肿瘤相
Tumor transformation involves multiple steps of tumor suppressor genes, protooncogenes and transcriptional regulation of gene mutations, resulting in abnormally expressed proteins and dysregulation of proliferation. In this series of tumor cells and through the following ways to escape the body’s immune surveillance and clearance: (1) tumor antigen defects: the tumor in the clonal evolution or the initial stage that down-regulated expression or does not express its specific antigen and MHC molecules; tumor phase