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目的探究气候因素对手足口病肠道病毒感染的影响。方法收集2009～2011年广州市的气候及某医院实验室诊断手足口病病例数据,应用单因素相关、多元线性回归检验气候因素与各肠道病毒报告例数之间的关联,并应用亚组分析探索影响的滞后作用。结果单因素分析结果表明周平均气温、湿度和露点与EV71、Cox A16和其他肠道病毒周报告例数存在正相关性,气压成负相关(P<0.05)。控制其他气候因素后,湿度、气温分别与EV71、Cox A16和其他肠道病毒例数有显著性联系,且亚组分析证实与2～3周后的例数关联最强(P<0.05)。结论气候因素,尤其湿度、气温可影响手足口病肠道病毒感染,在高热高湿度的季节,预防控制措施更可减少感染手足口病肠道病毒的危险性。
Objective To investigate the effect of climatic factors on enterovirus infection in hand-foot-mouth disease. Methods The data of the diagnosis of hand-foot-mouth disease in a hospital in Guangzhou from 2009 to 2011 were collected. The correlation between climatic factors and the number of reported cases of enterovirus was tested by single factor correlation and multiple linear regression. The subgroups Analysis to explore the lagging effect of the impact. Results The results of univariate analysis showed that there was a positive correlation between weekly average temperature, humidity and dew point and EV71, Cox A16 and other reported cases of enteroviruses week, and negatively correlated with barometric pressure (P <0.05). After controlling for other climatic factors, humidity, temperature were significantly associated with EV71, Cox A16 and other enterovirus cases, respectively, and subgroup analysis showed the strongest association with the number of cases after 2 to 3 weeks (P <0.05). Conclusion Climatic factors, especially humidity and temperature, may affect enterovirus infection of HFMD. In the season of high fever and high humidity, prevention and control measures may also reduce the risk of enterovirus infection in HFMD.