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目的探讨阿替洛尔治疗慢性心力衰竭临床疗效。方法116例慢性心力衰竭患者随机分为常规治疗组(血管紧张素转换酶抑制剂+利尿剂+地高辛)和阿替洛尔组(常规治疗组药物+阿替洛尔)。随访两年,观察治疗前后的左室舒张末期内径、左室射血分数、NYHA分级以及心率、血压变化。结果两组治疗后均较治疗前左室舒张末期内径及NYHA分级下降,左室射血分数升高。阿替洛尔组的上述变化均常规治疗组明显。而且随阿替洛尔应用时间的延长,疗效更显著,病死率、年住院率明显降。结论长期使用阿替洛尔能阻止心脏扩大,逆转心室重构,改善慢性心力衰竭患者的心功能。
Objective To investigate the clinical efficacy of atenolol in the treatment of chronic heart failure. Methods One hundred and sixteen patients with chronic heart failure were randomly divided into routine treatment group (angiotensin converting enzyme inhibitor plus diuretic plus digoxin) and atenolol group (conventional treatment group plus atenolol). Followed up for two years, before and after treatment of left ventricular end-diastolic diameter, left ventricular ejection fraction, NYHA classification and heart rate, blood pressure changes. Results Compared with before treatment, left ventricular end-diastolic diameter, NYHA classification and left ventricular ejection fraction increased after treatment in both groups. Atenolol group of the above changes were routine treatment group. And with the prolonged use of atenolol, the curative effect is more significant, case fatality rate, annual hospitalization rate decreased significantly. Conclusion Long-term use of atenolol can prevent cardiac enlargement, reverse ventricular remodeling and improve cardiac function in patients with chronic heart failure.