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目的探讨骨髓增生异常综合征(MDS)发病到死亡时间、最后转归及死因。方法回顾性分析23例MDS的临床资料。结果①治疗无效死亡的MDS从发病到死亡时间最短8+月,最长20+年;②多数转为急性髓系白血病(18例),无一例转变为淋巴细胞白血病;③死因中颅内出血14例,消化道出血5例,全身衰竭4例。结论死亡的MDS中,发病到死亡时间从8个月到20年不等;转归、转变为急性髓系白血病占78.26%;死因中颅内出血超过半数(60.86%)。
Objective To investigate the incidence of myelodysplastic syndrome (MDS) to the time of death, the final outcome and the cause of death. Methods Retrospective analysis of 23 cases of MDS clinical data. Results ① The MDS with ineffective treatment had the shortest time from onset to death of 8+ months up to 20+ years; ② Most of the patients turned to acute myeloid leukemia (18 cases), none of them turned to lymphocytic leukemia; ③ The intracranial hemorrhage of the cause of death was 14 Cases, gastrointestinal bleeding in 5 cases, 4 cases of systemic failure. Conclusions The morbidity and mortality of MDS in different ages ranged from 8 months to 20 years. The prognosis was 78.26% in acute myeloid leukemia and more than 50% in intracranial hemorrhage (60.86%).