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口服混悬液易于定量、吞服方便,易被小儿及老年病人所接受。混悬液虽然有许多优点,但控释混悬液常不能在最佳吸收部位滞留足够长的时间,因而影响生物利用度。另外,由于加入分散剂而使粘度增大,从而影响药物的吸收,导致生物利用度降低。本文报道了具有网状结构分散剂和表面粗糙微球的混悬液体系,该体系分散性好且粘度较低,其药物吸收变异系数(CV)小。另外证实,混悬液口服后在胃肠道的滞留时间也能影响生物利用度。低粘度混悬液分两步制备。第一步,采用
Oral suspension is easy to quantify, easy to swallow, easily accepted by children and elderly patients. While suspensions have many advantages, controlled-release suspensions often fail to persist at optimal absorption sites for long enough to affect bioavailability. In addition, due to the addition of a dispersant to increase the viscosity, thereby affecting the absorption of the drug, resulting in reduced bioavailability. In this paper, a suspension system with a network structure dispersant and surface-roughed microspheres is reported. The system has good dispersibility and low viscosity, and has a small coefficient of variation (CV) of drug absorption. In addition, it has been confirmed that the residence time in the gastrointestinal tract after oral administration of the suspension can also affect the bioavailability. Low-viscosity suspensions are prepared in two steps. The first step, adopted