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β阻滞剂已广泛用于治疗高血压病,但是在某些方面尚需进一步探讨。所谓“纯”β阻滞剂一般不降低周围血管阻力,但可减少心搏出量,因此,其血流动力学影响对血管阻力增加为特征的高血压病人(如许多老年高血压病患者)不相适应。其二,β阻滞剂通常能降低HDL胆固醇和增加LDL胆固醇,因此,这类药物有潜在的促动脉硬化形成作用。β阻滞剂与扩张血管制剂联合治疗可增加临床疗效及改善血流动力学。β阻滞剂可降低由许多扩血管剂所引起的反射性心动过速。因为联合用药增加药物的效应,现注意
Beta blockers have been widely used in the treatment of hypertension, but in some aspects still need to be further explored. The so-called “pure” beta blockers generally do not reduce peripheral vascular resistance, but reduce cardiac output, therefore, their hemodynamic effects on vascular resistance characteristics of hypertensive patients (such as many elderly hypertensive patients) Not suitable. Second, beta blockers usually lower HDL cholesterol and increase LDL cholesterol, so these drugs have a potential role in promoting atherosclerosis. Combination therapy with beta blockers and dilated blood vessels increases clinical efficacy and improves hemodynamics. Beta blockers reduce the reflex tachycardia caused by many vasodilators. Because the combination of drugs to increase the effect, are now noted