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目的 :观察氟喹诺酮类药物在治疗结核中的临床疗效。方法 :在HLZE四联方案中加入OFLX ,静脉滴注一个月而后改用口服药 ,连续用药 5个月。结果 :HLZE加用OFLX痰菌转阴率明显高于单纯应用HLZE。结论 :氟喹诺酮类药物是治疗肺结核尤其是涂阳肺结核中值得推荐的有效抗菌药。
Objective: To observe the clinical efficacy of fluoroquinolones in the treatment of tuberculosis. METHODS: OFLX was added to the HLZE quadruple protocol by intravenous infusion for one month and then to oral administration for 5 months. Results: HLZE with OFLX sputum negative conversion rate was significantly higher than the simple application of HLZE. Conclusion: Fluoroquinolones are effective antimicrobial agents recommended for the treatment of pulmonary tuberculosis, especially smear positive pulmonary tuberculosis.