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本文观察了我科自1987年3月~1990年6月收治的58例急性、亚急性重症肝炎的内毒素血症对疾病的发生、发展及预后估计的作用。结果表明,内毒素血症在急性肝炎的发生率是50%,重症肝炎为100%,而且重症肝炎的内毒素水平高于急性肝炎,内毒素水平大于与小于250pg/ml两组,病死与存活率有非常显著性差异。内毒素水平与PT延长秒、Fn、Lpo水平有关。肝功能损害形成了内毒素血症,内毒素血症加重了肝功能损害,形成了恶性循环。阻断恶性循环,抗内毒素血症治疗是重要的一部分。我们采用了“重肝Ⅰ号”治疗,取得了较满意的效果。
This article observes our department since March 1987 ~ June 1990 admitted 58 cases of acute, subacute severe hepatitis endotoxemia on the occurrence, development and prognosis of the role. The results showed that the incidence of endotoxemia in acute hepatitis was 50%, severe hepatitis was 100%, and severe hepatitis endotoxin levels higher than acute hepatitis, endotoxin levels greater than and less than 250pg / ml two groups, death and survival Rate is very significant difference. Endotoxin levels and PT extended second, Fn, Lpo levels. Liver damage caused by endotoxemia, endotoxemia aggravate liver damage, forming a vicious cycle. Block the vicious cycle, anti-endotoxemia treatment is an important part. We adopted the “heavy liver Ⅰ” treatment, and achieved satisfactory results.