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目的探讨青年女性乳腺癌的临床和病理特征。方法回顾性分析82例青年女性乳腺癌的临床和病理资料,并且随机抽取50例中老年患者作为对照组。结果青年女性乳腺癌临床症状隐匿,误诊率为45.12%(37/82),病理类型以浸润性癌为主。青年组在组织分级、病理分期、淋巴结转移率、ER和c-erbB-2阳性表达率与中老年组均有差异性(P<0.05)。青年女性乳腺癌患者按病程分为6个月以内、6～12个月和12个月以上三组,病理分期和淋巴结转移率在不同组之间有差异性(P<0.01)。结论青年女性乳腺癌侵袭性强。随病程进展,患者病理分期晚,淋巴结转移率高,早期诊断有助青年女性乳腺癌的治疗。
Objective To investigate the clinical and pathological features of breast cancer in young women. Methods The clinical and pathological data of 82 young women with breast cancer were retrospectively analyzed. Fifty middle-aged and elderly patients were randomly selected as the control group. Results The clinical manifestations of breast cancer in young women were occult. The rate of misdiagnosis was 45.12% (37/82). The pathological type was mainly invasive carcinoma. There was a significant difference between the young group and the middle-aged and elderly patients in the histological grade, pathological stage, lymph node metastasis, ER and c-erbB-2 expression (P <0.05). The young female breast cancer patients were divided into 6 months, 6 to 12 months and 12 months or more according to the course of the disease. The pathological stage and lymph node metastasis rate were different in different groups (P <0.01). Conclusion Young women have aggressive breast cancer. With the progression of the disease, patients with pathological stage late, high rate of lymph node metastasis, early diagnosis can help young women with breast cancer treatment.