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旨在揭示特定频率及强度微波辐射对周围神经胶质细胞的影响。对周围神经系统神经胶质细胞系雪旺细胞进行微波辐射后,通过检测细胞活性、细胞凋亡率,蛋白质水平的超级氧化物歧化酶(SOD)和过氧化氢酶(CAT)的活性以及胞内物质活性氧簇(ROS)和谷胱甘肽(GSH)的含量,探讨微波辐射对神经胶质细胞的影响。经频率为2.45GHz,功率密度为1mW/cm2的微波辐射后,雪旺细胞的过氧化氢酶和超氧化物歧化酶的活力随时间的延长而升高,其细胞活性随时间的延长而降低,同时细胞凋亡率升高。模拟移动电话微波辐射将诱导大鼠神经胶质细胞出现细胞凋亡,同时细胞抗氧化系统的积极响应说明氧化损伤可能是导致细胞凋亡的原因之一。
To reveal the specific frequency and intensity of microwave radiation on peripheral glial cells. Peripheral neurons glial cell line Schwann cells were exposed to microwave radiation. The activity of cell, the rate of apoptosis, the activities of superoxide dismutase (SOD) and catalase (CAT) at the protein level, Content of reactive oxygen species (ROS) and glutathione (GSH), and explore the effect of microwave radiation on glial cells. The activity of catalase and superoxide dismutase (SOD) and superoxide dismutase (SOD) in Schwann cells increased with time after microwave radiation with a frequency of 2.45GHz and a power density of 1mW / cm2. The cell viability decreased with time , While the rate of apoptosis increased. Simulated mobile phone microwave radiation will induce apoptosis in rat glial cells, and the positive response of cellular anti-oxidant system suggests that oxidative damage may be one of the reasons leading to apoptosis.