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日前,来自加州大学欧文分校的Paolo Sassone-Corsi领导的一支研究小组发现,高脂饮食通过影响控制身体生物钟的分子机制,调控了肝脏的代谢功能。这些昼夜节律如果遭到破坏,就有可能促成糖尿病、肥胖和高血压等代谢异常类疾病。而好消息是,这项研究还发现恢复平衡的、低脂饮食可使昼夜节律正常化。这些发现表明,生物钟能够根据饮食的营养含量来进行自身重编程。这有可能促使鉴别出控制饮食的新型药物靶点。相关研究论文刊登在了近期出版的《细胞》杂志上。在几乎所有的生物体内,24小时昼夜节律支配了基本的生理功能。生物钟是我们身体中的内在时间追踪系统,它能够预
A team led by Paolo Sassone-Corsi of the University of California, Irvine, recently found that a high-fat diet regulates the liver’s metabolic function by influencing the molecular mechanisms that control the body’s circadian clock. If these circadian rhythms are damaged, they may cause metabolic disorders such as diabetes, obesity and hypertension. The good news is that the study also found that a balanced, low-fat diet normalizes circadian rhythms. These findings show that the circadian clock can self-reprogram according to the nutritional content of the diet. This may prompt the identification of novel drug targets that control the diet. Related research papers published in the recently published “Cell” magazine. In almost all organisms, the 24-hour circadian rhythm dominates the basic physiological functions. The biological clock is an intrinsic time tracking system in our body that can be pre-programmed