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本文采用双盲法观察蝙蝠葛碱(Dauricine)治疗34例频发性期前收缩患者的临床疗效,并使用ICG、STI方法测定服药前后血流动力学的变化。服用Dauricine四周后抗心律失常临床疗效达94.1%。该药对PEP、PEP/LVET、HI、CO、CI、LVW、TPR、MAP均无明显改变。HR下降和LVET增加虽有统计学意义,但均在正常值范围。结果提示Dauricine有稳定、可靠的抗心律失常作用,同时对心功能未见明显的影响。
In this paper, we observed the clinical efficacy of Dauricine in 34 patients with frequent premature contractions by double-blind method. The changes of hemodynamics were measured by ICG and STI before and after treatment. After four weeks of taking Dauricine anti-arrhythmia clinical efficacy of 94.1%. The drug on PEP, PEP / LVET, HI, CO, CI, LVW, TPR, MAP no significant change. The decrease of HR and the increase of LVET were statistically significant, but all were in the normal range. The results suggest that Dauricine has a stable and reliable anti-arrhythmic effect with no significant effect on cardiac function.