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目的 探讨超敏肌钙蛋白Ⅰ(high-sensitivity troponinⅠ,hs-TNI)和肌酸激酶同工酶质量(creatine kinase-MB mass,CK-Mbmass)联合检测对急性心肌梗死(acute myocardial infarction,AMI)的应用价值.方法 采用化学发光法,对哈尔滨医科大学附属第一医院73例AMI患者和110例健康体检者hs-TNⅠ水平和CK-Mbmass进行检测.结果 AMI组hs-TnI、CK-Mbmass各阶段水平及阳性率均明显高于正常对照组(P＜0.05);AMI组hs-TNI各阶段阳性率(93％ 、97％ 、100％ 、78％)与CK-Mbmass阳性率(25％ 、56％ 、84％ 、11％)相比较,hs-TNI的敏感性和特异性高于CK-Mbmass,但在2-3 d时hs-TNI具有78％ 的阳性率,诊断窗口期长,而CK-Mbmass 2-3 d时阳性率已降为11％,大多说明治疗有效.结论hs-TNI和CK-Mbmass联合检测对AMI的诊断、治疗和预后判断有重要意义.“,”Objective To explore the application value of combined detection of high-sensitivity tropo-nin Ⅰ(hs-TNI)and creatine kinase-MB mass(CK-MBmass)for acute myocardial infarction(AMI). Methods The levels of hs-TNⅠ and CK-MBmass were determined by chemiluminescence in 110 healthy patients and 73 patients with AMI. Results The levels and positive rate of hs-TNI and CK-MBmass in patients with AMI were significantly higher than those in the normal control group(P ＜ 0. 05). The positive rates of hs-TNI at all stages of patients whith AMI were 93％ ,97％ ,100％ and 78％ ,while the positive rate of ck-mbmass was 25％ , 56％ ,84％ and 11％ ,the sensitivity and specificity of hs-TNⅠ were higher than CK-Mbmass. As well as,the positive rate of hs-TN Ⅰ in 2 ～ 3 days had a long window period,while the positive rate of CK-Mbmass at 2-3 days had been reduced to 11％ ,which indicatied that most treatments were effective. Conclusion The com-bined detection of hs-TNI and CK-Mbmass is important to guide clinical therapy and judge prognostic of AMI.