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用紫外分光光度法研究微量穴醚(2.2.2)的检测方法,并将该方法用于氟[18F]脱氧葡萄糖中微量穴醚(2.2.2)测定.将适量苯甲醛加入硝酸铅缓冲溶液中配制储备液,使溶液在250 nm检测波长处的吸收曲线为一平台,用储备液和微量穴醚(2.2.2)配制供试液,用紫外分光光度法检测.穴醚(2.2.2)的线性范围为1.0~10.0μg/mL,相关系数0.999 5,平均回收率为100.5%(n=5),相对标准偏差为2.24%,方法检出限(3σ)为0.15μg/mL.该方法用于氟[18F]脱氧葡萄糖中微量穴醚(2.2.2)测定,结果良好.该方法精密度高,准确性好,可用于微量穴醚(2.2.2)测定.
The method for the determination of trace amount of cryptands (2.2.2) by ultraviolet spectrophotometry was studied and the method was applied to the determination of trace amount of ethers (2.2.2) in fluorodeoxyglucose [18F] deoxyglucose.A suitable amount of benzaldehyde was added to lead nitrate buffer solution In the preparation of the stock solution, the solution at 250 nm detection wavelength absorption curve as a platform, with a stock solution and a small amount of ether (2.2.2) prepared for the test solution, detected by UV spectrophotometry Cryptomethone (2.2.2 ) Showed a linear range of 1.0 ~ 10.0μg / mL with a correlation coefficient of 0.999 5 and an average recovery of 100.5% (n = 5) with a relative standard deviation of 2.24% and a limit of detection (3σ) of 0.15μg / mL. The method was applied to the determination of trace amount of phenolic ether (2.2.2) in fluorine [18F] deoxyglucose with good results.