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目的 评价谷氨酰胺强化的肠内营养对氟尿嘧啶 (5 Fu)化疗大鼠肠屏障的影响。方法 30只胃造瘘术后的Wistar大鼠随机分为饲料组 (A组 )、肠内营养组 (B组 )和谷氨酰胺强化的肠内营养组 (C组 ) ,每组10只。术后第 4天用 5 Fu化疗 ,比较它们的体重变化、小肠和结肠结构、血浆谷氨酰胺水平、肠通透性 (L/M )及细菌移位率 (BTR)等指标。结果 B组体重丢失 (- 6 6± 5 2 )g (P <0 0 1) ,C组体重无明显变化 ;C组小肠结构优于B组 (P <0 0 1)与A组相似 (P >0 0 5 ) ,但C组结肠结构不及A组 (P <0 0 1)而与B组相似 (P >0 0 5 )。化疗后与A组比 ,C组L/M无明显变化 (P >0 0 5 ) ,而B组上升 (P <0 0 1) ;C组细菌移位率 (30 % )低于B组 (70 % ) (P <0 0 5 ) ,与A组 (2 0 % )无显著差异 (P >0 0 5 )。结论 谷氨酰胺强化的肠内营养能保护 5 Fu化疗大鼠的肠屏障。
Objective To evaluate the effect of glutamine-enriched enteral nutrition on the intestinal barrier of rats treated with fluorouracil (5 Fu). Methods Thirty Wistar rats after gastrostomy were randomly divided into the feed group (group A), the enteral nutrition group (group B), and the glutamine-enriched enteral nutrition group (group C), 10 in each group. On the fourth postoperative day, 5 Fu chemotherapy was used to compare their weight changes, intestinal and colonic structures, plasma glutamine levels, intestinal permeability (L/M), and bacterial translocation rate (BTR). Results The body weight of group B was (- 6 6 ± 5 2 ) g (P <0 01), and there was no obvious change in body weight in group C. The structure of small intestine in group C was better than that in group B (P <0 01) and group A was similar (P >0 0 5 ), but the colon structure of group C was less than that of group A (P <0 01) and similar to that of group B (P > 0 05). After chemotherapy, compared with group A, there was no significant change in L/M in group C (P > 0.05), but increased in group B (P <0 01); the bacterial translocation rate in group C (30%) was lower than that in group B ( 70%) (P <0 0 5) was not significantly different from group A (20%) (P > 0 0 5). Conclusion Glutamine-enriched enteral nutrition can protect the intestinal barrier of 5 Fu rats.